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KMID : 0923620150150030161
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Immune Network
2015 Volume.15 No. 3 p.161 ~ p.166
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Early Growth Response-1 Plays a Non-redundant Role in the Differentiation of B Cells into Plasma Cells
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:Oh Yeon-Kyung
:Jang Eun-kyeong/:Paik Doo-Jin/:Youn Jee-hee
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Abstract
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Early growth response (Egr)-1 is a Cys2-His2-type zincfinger transcription factor. It has been shown to induce survival and proliferation of immature and mature B cells, respectively, but its role in the differentiation of B cells into plasma cells remains unclear. To examine the effects of Egr-1 deficiency on the activation of B cells, naive B cells from Egr1-/- mice and their wild-type (WT) littermates were activated to proliferate and differentiate, and then assayed by FACS. Proportions of cells undergoing proliferation and apoptosis did not differ between Egr1-/- and WT mice. However, Egr1-/- B cells gave rise to fewer plasma cells than WT B cells. Consistently, Egr1-/- mice produced significantly lower titer of antigen-specific IgG than their WT littermates upon immunization. Our results demonstrate that Egr-1 participates in the differentiation program of B cells into plasma cells, while it is dispensable for the proliferation and survival of mature B cells.
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KEYWORD
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Egr1, B cells, Plasma cells, Differentiation, Antibody
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